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Pregnant or breastfeeding women

TB-500 is most commonly injected subcutaneously in the abdominal fat pad, but intramuscular injection is also used depending on the protocol

The Akkermansia species muciniphila has been shown to alter glucose and lipid metabolism as well as intestinal immunity 86 , to strengthen the integrity of the enterocyte monolayer to possibly improve intestinal barrier integrity 87 , and to improve glucose tolerance and reduce visceral adipose tissue inflammation in mice fed an HFD 88

doi: 10.1016/bs.vh.2022.01.011